von Cramon, “Measuring the cortical thickness

Besides normal aging, a number of brain diseases are known to reduce the amount of grey matter in the brain. To better understand the nature and progression of these disease processes, quantitative measurements of relevant brain structures, such as the regional cortical thickness, are highly desirable. Starting from high resolution volu-metric MR images of the human head, a reliable segmenta-tion procedure for the grey matter compartment is described which allows thickness measurements at sub-voxel resolu-tion. Simulation experiments and comparisons with pub-lished data from histological examinations prove the valid-ity of results. 1